Hydrochloric Acid → 2-(Acetylmethyl)-3-fluoro-4-phthalimidonitrobenzene

反応式

C[O:2][C:3](OC)([CH3:26])[CH2:4][C:5]1[C:10]([F:11])=[C:9]([N:12]2[C:16](=[O:17])[C:15]3=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]3[C:13]2=[O:22])[CH:8]=[CH:7][C:6]=1[N+:23]([O-:25])=[O:24].Cl>C1COCC1.CO>[C:3]([CH2:4][C:5]1[C:10]([F:11])=[C:9]([N:12]2[C:13](=[O:22])[C:14]3=[CH:21][CH:20]=[CH:19][CH:18]=[C:15]3[C:16]2=[O:17])[CH:8]=[CH:7][C:6]=1[N+:23]([O-:25])=[O:24])(=[O:2])[CH3:26]

参加物

実験手順

2-(2,2-Dimethoxypropyl)-3-fluoro-4-phthalimidonitrobenzene (5.5 g, 14 mmol) was suspended in a mixture of THF (200 ml) and methanol (100 ml). HCl 2N (1 ml) was added and the mixture was stirred at ambient temperature for 30 minutes. The solvents were evaporated off and the residue redissolved in methylene chloride, dried (MgSO4), filtered and the solvent evaporated off. The residue was triturated in pentane and collected by filtration to give 2-(acetylmethyl)-3-fluoro-4-phthalimidonitrobenzene (4.8 g, 100%) as a pale yellow solid.