6-Methoxy-1H-benzimidazole-2-carboxylic acid → 6-Hydroxy-1H-benzimidazole-2-carboxylic acid
反応式
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[C:9]([C:11]([OH:13])=[O:12])[NH:8][C:7]=2[CH:14]=1>Br>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[C:9]([C:11]([OH:13])=[O:12])[NH:8][C:7]=2[CH:14]=1参加物
3
反応条件
- 温度
- 110 °C
実験手順
A mixture of 26.0 g (105 mmol) of 6-methoxy-1H-benzoimidazole-2-carboxylic acid butilamide and 780 ml of 48% aqueus hydrobromic acid is stirred at 110° C. for 8 h, then refluxed for 12 h. The mixture is cooled to room temperature, the precipitated product is filtered off, washed with water until pH neutral and dried to yield 14.3 g (76.2%) of the title compound. Mp.: 206-207° C. (water).
後処理
- temperaturerefluxed for 12 h
- temperatureThe mixture is cooled to room temperature
- filtrationthe precipitated product is filtered off
- washwashed with water until pH neutral
- customdried
出典と根拠
- ORDレコード
- ord-904d5b6c31354a6abe64c77ae680734b
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07375116B2
反応ノート
読み込み中…