1-Benzylpiperidin-4-yl acetate → Piperidin-4-yl acetate
反応式
[C:1]([O:4][CH:5]1[CH2:10][CH2:9][N:8](CC2C=CC=CC=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2].[H][H]>C(O)C.O.[Pd]>[C:1]([O:4][CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:3])[CH3:2]参加物
6
実験手順
10% Pd/C (500 mg) was added to a solution of 1-benzylpiperidin-4-yl acetate [(11 g, 47 mmol), J. Org. Chem. 68(2), 613-616; 2003] in a mixture of ethanol and water (90:10, 110 mL), and the mixture was stirred at 60° C., under 60 psi of hydrogen gas for 18 hours. The reaction mixture was then filtered through Arbocel®, washing through with ethanol, and the filtrate was concentrated in vacuo to afford the title product in 92% yield, 7.2 g.
後処理
- filtrationThe reaction mixture was then filtered through Arbocel®
- washwashing through with ethanol
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-ae33774cc2754a1bbda30b6e3d8d128e
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08207198B2
反応ノート
読み込み中…