Trifluoroacetic acid → HCID 69282442、化合物

HRID 2223247

反応式

HRID 2223247 の反応式
C(OC(=O)[NH:7][CH:8]([CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)[C:9]([N:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12]1)=[O:10])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][CH:8]([CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)[C:9]([N:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12]1)=[O:10]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 69900649[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

生成物 1

HCID 69282442HCID 69282442、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (2.90 g, 6.91 mmol) was dissolved in CH2Cl2 (10 ml). Trifluoroacetic acid (10 ml) was added and the mixture was stirred for 90 minutes at r.t. until analytical HPLC indicated complete consumption of the starting material. The solvent was evaporated, the residue was taken up in ethyl acetate, washed (water), and dried (Na2SO4). After evaporation of the solvent, the title compound, MS: m/e=320.4 (M+H+), (1.73 g, 69%) was obtained by chromatographic purification of the residue (silica gel, MeOH, CH2Cl2).

後処理

  1. customconsumption of the starting material
  2. customThe solvent was evaporated
  3. washwashed (water)
  4. dry with materialdried (Na2SO4)
  5. customAfter evaporation of the solvent

出典と根拠

ORDレコード
ord-05eaa31a454444a3bfa6c62e77e4dcba
出典データセット
uspto-grants-2008_05
特許番号
US07375099B2

関連ノート

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