Methyl iodide → (S)-Glycidyl N-methyl-N-Methanesulfonyl-p-Aminophenyl Ether
反応式
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C@H:14]2[O:16][CH2:15]2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].[C:17](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:17][N:5]([S:2]([CH3:1])(=[O:3])=[O:4])[C:6]1[CH:7]=[CH:8][C:9]([O:12][CH2:13][C@H:14]2[O:16][CH2:15]2)=[CH:10][CH:11]=1参加物
5
実験手順
A solution of compound 3-S (0.243 g, 1 mmol) and potassium carbonate (0.166 g, 1.2 mmol) in 20 ml acetone was stirred for 1 hour at room temperature, then methyl iodide (0.142 g, 0.062 ml, 1 mmol) was added dropwise at room temperature. After stirring for 8 hours, the reaction was filtered and the solvent evaporated to furnish a white solid that was used directly in the next step (0.2 g, 78% yield).
後処理
- filtrationthe reaction was filtered
- customthe solvent evaporated
- customto furnish a white solid that
出典と根拠
- ORDレコード
- ord-5355fc12a8214739a0cfcad600625718
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07375136B2
反応ノート
読み込み中…