Sodium Carbonate → 2-Thiophen-2-yl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine

HRID 2223491ノート

反応式

HRID 2223491 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:7][C:8]2[CH2:9][N:10](C(=O)C)[CH2:11][CH2:12][C:13]=2[N:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>Cl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:7][C:8]2[CH2:9][NH:10][CH2:11][CH2:12][C:13]=2[N:14]=1

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 685332071-(2-Thiophen-2-yl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl)-ethanone

生成物 1

HCID 625480832-Thiophen-2-yl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

1 mmol of 1-(2-Thiophen-2-yl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl)-ethanone was refluxed for 30 min. in 15 ml of 2 M aqueous hydrochloric acid. The reaction mixture was cooled and made alkaline by addition of sodium carbonate. Extraction with ethyl acetate yields the title compound as a brownish solid. MS (m/e): 223.3 (M+H+).

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionExtraction with ethyl acetate

出典と根拠

ORDレコード
ord-0115d2f90e4e4273b2a203d0408d0345
出典データセット
uspto-grants-2008_05
特許番号
US07375226B2

反応ノート

読み込み中…