ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Water → (E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-non-6-enoic acid [(3S,6R)-6-(6-amino-hexyloxy)-1-methyl-2-oxo-azepan-3-yl]-amide

HRID 2224030
ノート
印刷プレビュー

反応式

HRID 2224030 の反応式
[N:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C@H:11]1[CH2:17][N:16]([CH3:18])[C:15](=[O:19])[C@@H:14]([NH:20][C:21](=[O:37])[C@H:22]([O:35][CH3:36])[C@H:23]([OH:34])[C@@H:24]([OH:33])[C@H:25]([OH:32])/[CH:26]=[CH:27]/[C:28]([CH3:31])([CH3:30])[CH3:29])[CH2:13][CH2:12]1)=[N+]=[N-].O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1.C(Cl)Cl>[NH2:1][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C@H:11]1[CH2:17][N:16]([CH3:18])[C:15](=[O:19])[C@@H:14]([NH:20][C:21](=[O:37])[C@H:22]([O:35][CH3:36])[C@H:23]([OH:34])[C@@H:24]([OH:33])[C@H:25]([OH:32])/[CH:26]=[CH:27]/[C:28]([CH3:29])([CH3:31])[CH3:30])[CH2:13][CH2:12]1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 59840149(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-non-6-enoic acid [(3S,6R)-6-(6-azido-hexyloxy)-1-methyl-2-oxo-azepan-3-yl]-amide

生成物 1

HCID 59716400(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-non-6-enoic acid [(3S,6R)-6-(6-amino-hexyloxy)-1-methyl-2-oxo-azepan-3-yl]-amide収率 85%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒
HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of (E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-non-6-enoic acid [(3S,6R)-6-(6-azido-hexyloxy)-1-methyl-2-oxo-azepan-3-yl]-amide (0.13 g, 0.25 mmol) in THF (2 mL) is added H2O and triphenylphosphine (0.120 g, 0.5 mmol). After 8 h the reaction solution is evaporated under vacuum to give a semisolid residue that is dissolved in CH2Cl2 (10 mL), adsorbed on silica and chromatographed (CH2Cl2/NH3 to 25% CH3OH/CH2Cl2/NH3 gradient) to give 0.106 g (85%) of (E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-non-6-enoic acid [(3S,6R)-6-(6-amino-hexyloxy)-1-methyl-2-oxo-azepan-3-yl]-amide as a white solid. MS (ESI) 502.1 (M+H)+

後処理

  1. customAfter 8 h the reaction solution is evaporated under vacuum
  2. customto give a semisolid residue that
  3. customchromatographed (CH2Cl2/NH3 to 25% CH3OH/CH2Cl2/NH3 gradient)

出典と根拠

ORDレコード
ord-3945053941e1499b92cd9903ee5bbb5d
出典データセット
uspto-grants-2008_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07378410B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート