Tert-Butyl nitrite → 3,5-Dibromo-2-methylpyridine
反応式
[Br:1][C:2]1[C:3](N)=[N:4][C:5]([CH3:9])=[C:6]([Br:8])[CH:7]=1.C(ON=O)(C)(C)C>C1COCC1>[Br:8][C:6]1[C:5]([CH3:9])=[N:4][CH:3]=[C:2]([Br:1])[CH:7]=1参加物
4
実験手順
To a solution of 3,5-dibromo-6-methyl-pyridin-2-ylamine (2.0 g, 7.5 mmol) in THF (75 mL) was added t-butylnitrite (1.5 mL, 12.6 mmol) and the reaction was heated to reflux for 2 hours. The reaction was concentrated in vacuo and purified by flash chromatography (SiO2, CH2Cl2) to give 52A (0.8 g 42%). HPLC Rt=2.77 min.
後処理
- temperaturethe reaction was heated
- temperatureto reflux for 2 hours
- concentrationThe reaction was concentrated in vacuo
- custompurified by flash chromatography (SiO2, CH2Cl2)
出典と根拠
- ORDレコード
- ord-047d0d3583784aa993554947dd91ce01
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07378426B2
反応ノート
読み込み中…