Hydrochloric Acid → HCID 178440201、化合物
反応式
[C:1]([NH:6][C:7]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:8]=1[C:9]([NH2:11])=[O:10])(=O)[CH2:2][CH2:3][CH3:4].[OH-].[Na+].Cl>C(O)C>[Cl:16][C:13]1[CH:12]=[C:8]2[C:7](=[CH:15][CH:14]=1)[N:6]=[C:1]([CH2:2][CH2:3][CH3:4])[N:11]=[C:9]2[OH:10]参加物
5
実験手順
Preparation D10, Step 2: 2-butyramido-5-chlorobenzamide (1.08 g, 4.49 mmol, 1 eq) was dissolved in ethanol (10 mL) at room temperature then 1N NaOH (13.46 mL, 13.5 mmol, 3 eq) added. Worked up after 15 minutes by adding 1N HCl to pH=2. Solids precipitated and were filtered and pumped under high vacuum to give 6-chloro-2-propylquinazolin-4-ol (810 mg) as a white solid. Yield=81%. Mass Spec (ESI) (M+H)+=223.0.
後処理
- customPreparation D10, Step 2
- customSolids precipitated
- filtrationwere filtered
出典と根拠
- ORDレコード
- ord-937e60ca85cd4cf3928f74161e595e41
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07378409B2
反応ノート
読み込み中…