Sodium Hydroxide → HCID 19004073、化合物

HRID 2225371ノート

反応式

HRID 2225371 の反応式
[OH-].[Na+].[CH:3]1[C:13]2[CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[C:9]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][C:25]([O:27]CC)=[O:26])[CH2:20][CH2:19]3)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1>CO>[CH:3]1[C:13]2[CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[C:9]([N:18]3[CH2:19][CH2:20][N:21]([CH2:24][C:25]([OH:27])=[O:26])[CH2:22][CH2:23]3)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 19004087HCID 19004087、化合物

生成物 1

HCID 19004073HCID 19004073、化合物収率 63.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2N Aqueous sodium hydroxide solution (5 ml) was added to a solution of 1.82 g of ethyl 4-(11H-dibenz[b,e]azepin-6-yl)-1-piperazineacetate in 18 ml of methanol. The solution was refluxed for 30 min and then concentrated. The residue was dissolved in hot water and the solution was neutralized with 0.5N hydrochloric acid. The precipitates were collected by filtration to give 1.06 g of colorless crystals, which were recrystallized from ethanol to give colorless granules, mp 181°-183° C. (decomp.).

後処理

  1. temperatureThe solution was refluxed for 30 min
  2. concentrationconcentrated
  3. dissolutionThe residue was dissolved in hot water
  4. filtrationThe precipitates were collected by filtration

出典と根拠

ORDレコード
ord-b6a08c05d4ed4dcca12e13a5b65b608c
出典データセット
uspto-grants-1994_09
特許番号
US05344828

反応ノート

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