1-Azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-one → 1-Aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-one

HRID 2225490ノート

反応式

HRID 2225490 の反応式
[N:1]([CH2:4][C:5]12[CH2:12][CH2:11][C:8]([CH3:13])([CH2:9][CH2:10]1)[C:7](=[O:14])[O:6]2)=[N+]=[N-].[H][H]>C(O)C.[Pt](=O)=O>[NH2:1][CH2:4][C:5]12[CH2:12][CH2:11][C:8]([CH3:13])([CH2:9][CH2:10]1)[C:7](=[O:14])[O:6]2

参加物

5

反応物 2

HCID 190047971-Azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 190047031-Aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-one収率 84.6%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

0.025 g of platinum dioxide was added to a solution of 0.6 g of 1-azidomethyl-4-methyl-2-oxabicyclo[2.2.2]octan-3-one (Example 29) in 30 ml of ethanol. The resultant solution was reacted for 14 hours under 3.5 atom hydrogen gas. After reaction, the catalyst was filtered out, and the solvent was removed in vacuo from the filtrate. As a result, 0.44 g of 1-aminomethyl-4-methyl-2-oxabicyclo[2.2.2]-octan-3-one was obtained as a pale yellow oil, which had the following physiochemical properties:

後処理

  1. customAfter reaction
  2. filtrationthe catalyst was filtered out
  3. customthe solvent was removed in vacuo from the filtrate

出典と根拠

ORDレコード
ord-651ea7f3fdfc4619b4c7a8a05981a4ef
出典データセット
uspto-grants-1994_09
特許番号
US05344845

反応ノート

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