Sinapic acid → HCID 178490513、化合物

HRID 2225526

反応式

HRID 2225526 の反応式
C([O:4][C:5]1[C:15]([O:16][CH3:17])=[CH:14][C:8]([CH:9]=[CH:10][C:11]([OH:13])=O)=[CH:7][C:6]=1[O:18][CH3:19])(=O)C.COC1C=C(C=C(OC)C=1O)C=CC(O)=O.P(Cl)(OCC)(OCC)=O.[CH3:45][N:46]([CH3:57])[CH2:47][CH2:48][NH:49][C@H:50]1[CH2:55][CH2:54][C@H:53]([CH3:56])[CH2:52][CH2:51]1>CN(C)C1C=CN=CC=1.C(Cl)Cl.C(N(CC)CC)C>[CH3:45][N:46]([CH3:57])[CH2:47][CH2:48][N:49]([C@H:50]1[CH2:51][CH2:52][C@H:53]([CH3:56])[CH2:54][CH2:55]1)[C:11](=[O:13])[CH:10]=[CH:9][C:8]1[CH:7]=[C:6]([O:18][CH3:19])[C:5]([OH:4])=[C:15]([O:16][CH3:17])[CH:14]=1

参加物

8

反応物 4

HCID 10743Sinapic acidHCID 13139Diethyl chlorophosphateHCID 536614803-[4-(Acetyloxy)-3,5-dimethoxyphenyl]prop-2-enoic acidHCID 178483797HCID 178483797、化合物

生成物 1

HCID 178490513HCID 178490513、化合物

試薬・触媒・溶媒 3

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒HCID 8471Triethylamine溶媒

実験手順

Using 2.9 g of 4-acetoxy-3,5-dimethyoxycinnamic acid derived from 3,5-dimethoxy-4-hydroxycinnamic acid by the acetylation thereof, 2.8 ml of diethyl chlorophosphate, 2.7 ml of triethylamine, 100 ml of methylene chloride, 3 ml of N-(2-dimethylaminoethyl)-trans-4-methylcyclohexylamine (Example 78), and 0.5 g of 4-dimethylaminopyridine, a reaction similar to that conducted in Example 75 was carried out. As a result, 1.95 g of N-(2-dimethylaminoethyl)-N-(trans-4-methylcyclohexyl)-3,5-dimethoxy-4-hydroxycinnamamide (a compound of the present invention) was obtained as a pale yellow oil, which had the following physiochemical properties:

出典と根拠

ORDレコード
ord-6a41895f3597499abb3902f25d1cc03e
出典データセット
uspto-grants-1994_09
特許番号
US05344845

関連ノート

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