4-[[2-(4-Chlorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester → 4-[[2-(4-Chlorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid
反応式
C[O:2][C:3](=[O:23])[C:4](=[O:22])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[Cl:21][C:18]1[CH:17]=[CH:16][C:15]([O:14][CH2:13][CH2:12][O:11][C:8]2[CH:9]=[CH:10][C:5]([C:4](=[O:22])[C:3]([OH:23])=[O:2])=[CH:6][CH:7]=2)=[CH:20][CH:19]=1参加物
4
実験手順
A mixture of 4-[[2-(4-chlorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.72 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided solids which were crystallized from diethyl ether-hexane to give 0.63 g of colorless 4-[[2-(4-chlorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 121°-122° C.