4-[[2-(Cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester → 4-[[2-(Cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid

HRID 2225700ノート

反応式

HRID 2225700 の反応式
C[O:2][C:3](=[O:22])[C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[CH:15]1([O:14][CH2:13][CH2:12][O:11][C:8]2[CH:7]=[CH:6][C:5]([C:4](=[O:21])[C:3]([OH:22])=[O:2])=[CH:10][CH:9]=2)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1

参加物

4

反応物 1

HCID 543210414-[[2-(Cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester

生成物 1

HCID 190043524-[[2-(Cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid収率 89.8%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A mixture of 4-[[2-(cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.7 g) in methanol (10 mL) and 0.5N sodium hydroxide (7 mL) was treated as in Example 19. Extraction with diethyl ether provided material which was crystallized from diethyl ether-hexane to give 0.6 g of colorless 4-[[2-(cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid, mp 96°-98° C.

後処理

  1. additionwas treated as in Example 19
  2. extractionExtraction with diethyl ether provided material which
  3. customwas crystallized from diethyl ether-hexane

出典と根拠

ORDレコード
ord-90b957c3af2c469c9d3603aee62c589e
出典データセット
uspto-grants-1994_09
特許番号
US05344843

反応ノート

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