Acetonitrile → 2-(1-(Methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-5-((1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidin-4-yl)methoxy)pyridine

HRID 222597ノート

反応式

HRID 222597 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH2:23][CH2:24][N:25]([S:28]([CH3:31])(=[O:30])=[O:29])[CH2:26][CH:27]=3)=C[C:17]=2F)[CH2:10][CH2:9]1)=O)(C)(C)C.C(=O)([O-])[O-].[K+].[K+].C(#[N:41])C.CS(O[CH2:47][C:48]1([C:51]([F:54])([F:53])[F:52])[CH2:50][CH2:49]1)(=O)=O>ClCCl.O>[CH3:31][S:28]([N:25]1[CH2:26][CH:27]=[C:22]([C:19]2[CH:20]=[CH:21][C:16]([O:15][CH2:14][CH:11]3[CH2:12][CH2:13][N:8]([CH2:47][C:48]4([C:51]([F:52])([F:53])[F:54])[CH2:49][CH2:50]4)[CH2:9][CH2:10]3)=[CH:17][N:41]=2)[CH2:23][CH2:24]1)(=[O:30])=[O:29]

参加物

7

反応物 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 668644984-[2-Fluoro-4-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-phenoxymethyl]-piperidine-1-carboxylic acid tert-butyl esterHCID 86649942(1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonate

生成物 1

HCID 581111522-(1-(Methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-5-((1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidin-4-yl)methoxy)pyridine収率 65.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
140 °C

実験手順

To Preparation 6 (206 mg, 0.586 mmol), potassium carbonate (243 mg, 1.76 mmol) and acetonitrile (2.93 mL, 56 mmol) in a microwave vial is added (1-(trifluoromethyl)cyclopropyl)methyl methanesulfonate (256 mg, 1.17 mmol). The microwave vial is sealed and heated at 140° C. for 2 h then 150° C. for 30 min in the Biotage microwave. The reaction is diluted with dichloromethane and water. The organic layer is separated and washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue is triturated with diethylether and the title product is collected via vacuum filtration to obtain 0.181 g of the title compound. MS (m/z) 474 (M+1).

後処理

  1. customThe microwave vial is sealed
  2. customThe organic layer is separated
  3. washwashed with brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe residue is triturated with diethylether
  8. filtrationthe title product is collected via vacuum filtration

出典と根拠

ORDレコード
ord-e3b419b5ca9c479392ca8f560c5c9e17
出典データセット
uspto-grants-2012_06
特許番号
US08207344B2

反応ノート

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