Triphenylphosphine → Methyl 4-[1-(4-pyridyl)piperidin-4-yl]oxyphenoxyacetate

HRID 2226

反応式

HRID 2226 の反応式
CCOC(/N=N/C(OCC)=O)=O.[N:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:24][CH2:23][CH:22]([OH:25])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1.O[C:27]1[CH:38]=[CH:37][C:30]([O:31][CH2:32][C:33]([O:35][CH3:36])=[O:34])=[CH:29][CH:28]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[N:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:24][CH2:23][CH:22]([O:25][C:27]3[CH:38]=[CH:37][C:30]([O:31][CH2:32][C:33]([O:35][CH3:36])=[O:34])=[CH:29][CH:28]=3)[CH2:21][CH2:20]2)=[CH:15][CH:14]=1

参加物

6

反応物 4

HCID 11776TriphenylphosphineHCID 602731Methyl 2-(4-hydroxyphenoxy)acetateHCID 5462977Diethyl azodicarboxylateHCID 234476191-(Pyridin-4-yl)piperidin-4-ol

生成物 1

HCID 18918626Methyl 4-[1-(4-pyridyl)piperidin-4-yl]oxyphenoxyacetate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
4 °C

実験手順

Diethylazodicarboxylate (0.47 ml) was added dropwise over 30 minutes to a stirred mixture of 1-(4-pyridyl)-4-piperidinol (534 mg), methyl 4-hydroxyphenoxyacetate (546 mg), triphenylphosphine (787 mg) and dry THF (30 ml) in an atmosphere of argon and cooled to 4° C. After 1 hour at 4° C., the mixture was allowed to reach ambient temperature and stirred for 48 hours. The solvent was removed by evaporation and the residue purified by flash chromatography on silica eluting with 5% v/v methanol/dichloromethane. Recrystallisation from ethyl acetate/hexane gave the title compound, 532 mg, as a white solid: m.p. 74°-76° C.; NMR (d6DMSO) δ 8.15(2H, bd), 6.89(6H, m), 4.71(2H, s), 4.50(1H, m), 3.70(2H, m), 3.69(3H, s), 3.23(2H, m), 1.96(2H, m), 1.62(2H, m); m/e 343 (M+H)+ ; calculated for C19H22N2O4 : C, 66.7; H, 6.5; N, 8.2. found: C, 66.2; H, 6.7; N, 8.2%.

後処理

  1. customto reach ambient temperature
  2. customThe solvent was removed by evaporation
  3. customthe residue purified by flash chromatography on silica eluting with 5% v/v methanol/dichloromethane
  4. customRecrystallisation from ethyl acetate/hexane

出典と根拠

ORDレコード
ord-0b7d284c41804ff1aae25f00491e423c
出典データセット
uspto-grants-1998_03
特許番号
US05728701

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