1-[N-benzyloxycarbonyl-(S)-alanyl]hexhydrofuro[3,4-b]pyrrole-2(S)-carboxylic acid → 1-[(S)-alanyl]hexahydrofuro[3,4-b]pyrrole-2(S)-carboxylic acid
反応式
C(OC([NH:11][C@H:12]([C:14]([N:16]1[C@H:20]([C:21]([OH:23])=[O:22])[CH2:19][CH:18]2[CH2:24][O:25][CH2:26][CH:17]12)=[O:15])[CH3:13])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]([C:14]([N:16]1[C@H:20]([C:21]([OH:23])=[O:22])[CH2:19][CH:18]2[CH2:24][O:25][CH2:26][CH:17]12)=[O:15])[CH3:13]参加物
4
実験手順
Dissolve 1-[N-benzyloxycarbonyl-(S)-alanyl]hexhydrofuro[3,4-b]pyrrole-2(S)-carboxylic acid in methanol. Add 10% palladium-on-charcoal and hydrogenate the mixture at atmospheric pressure. Filter the mixture and concentrate in vacuo to give 1-[(S)-alanyl]hexahydrofuro[3,4-b]pyrrole-2(S)-carboxylic acid.
後処理
- filtrationFilter the mixture
- concentrationconcentrate in vacuo
出典と根拠
- ORDレコード
- ord-40d263f00cae47d9abf168bf7bf0d4ca
- 出典データセット
- uspto-grants-1994_09
- 特許番号
- US05348944
反応ノート
読み込み中…