Sodium Iodide → Ethyl 4-iodo-3-oxobutanoate

HRID 2226657ノート

反応式

HRID 2226657 の反応式
[I-:1].[Na+].Cl[CH2:4][C:5](=[O:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]>CC(C)=O.CCCCC.O.C(OCC)(=O)C>[I:1][CH2:4][C:5](=[O:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]

参加物

7

反応物 2

HCID 5238Sodium Iodide2 回HCID 69484Ethyl 4-chloroacetoacetate

生成物 1

HCID 12779728Ethyl 4-iodo-3-oxobutanoate

試薬・触媒・溶媒 4

HCID 180Acetone溶媒HCID 962Water溶媒HCID 8003Pentane溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
0 °C

実験手順

Sodium iodide (228 g) was dissolved in acetone (135 mL) and cooled to 0° C. 4-chloro-3-oxobutanoic acid, ethyl ester (5.0 g) was added to the sodium iodide solution and the mixture was stirred at 0° C. for 20 minutes. It was diluted with pentane (135 mL) and water (135 mL). The reaction mixture was diluted with ethyl acetate and washed with water, brine and dried over anhydrous sodium sulfate to give an intermediate (4-Iodo-3-oxobutanoic acid, ethyl ester; 6.2 g yield).

後処理

  1. washwashed with water, brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. customto give

出典と根拠

ORDレコード
ord-31734ba6240e48b099acd4eb53137c50
出典データセット
uspto-grants-1994_09
特許番号
US05349069

反応ノート

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