Diethyl Ether → 5-Methyl-3-[[2-[[[4-(tetradecyloxy)phenyl]acetyl]amino]phenyl]methyl]thiazolium bromide

HRID 2227039ノート

反応式

HRID 2227039 の反応式
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10](=[O:33])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:14][CH:13]=1.[CH3:34][C:35]1[S:39][CH:38]=[N:37][CH:36]=1.CCOCC>C1(C)C=CC=CC=1>[Br-:1].[CH3:34][C:35]1[S:39][CH:38]=[N+:37]([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:9][C:10](=[O:33])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:14][CH:13]=2)[CH:36]=1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 1379805-MethylthiazoleHCID 10391829N-[2-(bromomethyl)phenyl]-4-(tetradecyloxy)benzeneacetamide

生成物 1

HCID 104387945-Methyl-3-[[2-[[[4-(tetradecyloxy)phenyl]acetyl]amino]phenyl]methyl]thiazolium bromide収率 89.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 3.0 g of N-[2-(bromomethyl)phenyl]-4-(tetradecyloxy)benzeneacetamide and 2.88 g of 5-methylthiazole in 25 ml of toluene is heated at reflux under argon for 2.5 hours. The mixture is poured into 200 ml of ether, cooled, the solid collected, washed with ether and dried to give 3.2 g of the desired product as a white powder, m.p. 124°-127° C.

後処理

  1. temperatureis heated
  2. temperatureat reflux under argon for 2.5 hours
  3. temperaturecooled
  4. customthe solid collected
  5. washwashed with ether
  6. customdried

出典と根拠

ORDレコード
ord-1e66f7589dd747b4bfb12ac1242c9a8a
出典データセット
uspto-grants-1994_09
特許番号
US05350759

反応ノート

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