Hydrochloric Acid → (4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

HRID 2227099ノート

反応式

HRID 2227099 の反応式
[OH-:1].[Na+].[CH3:3][C:4]([CH3:17])=[CH:5][CH2:6][CH2:7][C:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]#N)[CH2:10][CH:9]=1.Cl.[OH2:19]>OO>[CH3:3][C:4]([CH3:17])=[CH:5][CH2:6][CH2:7][C:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([OH:19])=[O:1])[CH2:10][CH:9]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 18471789(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

生成物 1

HCID 18471803(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

試薬・触媒・溶媒 1

HCID 784Hydrogen Peroxide溶媒

実験手順

To a solution of sodium hydroxide (10.5 g) in water (150 mL) and 30% hydrogen peroxide (50 mL) is added the nitrile 2A (R=4-Methyl-3-pentenyl) (10 g). The reaction mixture is stirred at reflux overnight. The reaction is then cooled to room temperature, and poured into a mixture of ice (30 g) and hydrochloric acid (22 mL). The acid product is extracted with ethyl acetate, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

後処理

  1. temperatureat reflux overnight
  2. extractionThe acid product is extracted with ethyl acetate
  3. washthe combined organic layers are washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationThe solution is concentrated in vacuo

出典と根拠

ORDレコード
ord-653a52b5aaee4cd8bec4f76a400e3192
出典データセット
uspto-grants-2002_07
特許番号
US06413448B1

反応ノート

読み込み中…