1-Propanol → 2-(Cyclopentyloxy)benzaldehyde
反応式
[O:1]=[CH:2][C:3]1[CH:11]=[CH:10][C:7](OC)=[C:5](O)[CH:4]=1.C[C:13]([CH3:16])([O-:15])[CH3:14].[K+].[CH2:18](O)[CH2:19]C>>[CH:13]1([O:15][C:4]2[CH:5]=[CH:7][CH:10]=[CH:11][C:3]=2[CH:2]=[O:1])[CH2:16][CH2:19][CH2:18][CH2:14]1参加物
4
実験手順
77.70 g (500 mmoles) of isovanillin and 69.40 g (600 mmoles) of 97% potassium t-butoxide (t-BuOK) dissolved in 800 ml of 1-propanol, 69.0 ml 630 mmoles), and the solution refluxed. After 3 hours another 9.25 g (80 mmoles) of t-BuOK were added at 80° C. and the suspension refluxed for another 3 hours. The solid was filtered off and the filtrate evaporated in vacuo to dryness. The residue was dissolved in ether and extracted with 1N NaOH. The ether phase was evaporated to dryness: 85.40 g (77.5%) of cyclopentyloxybenzaldehyde was isolated.
後処理
- temperature69.0 ml 630 mmoles), and the solution refluxed
- temperaturethe suspension refluxed for another 3 hours
- filtrationThe solid was filtered off
- customthe filtrate evaporated in vacuo to dryness
- dissolutionThe residue was dissolved in ether
- extractionextracted with 1N NaOH
- customThe ether phase was evaporated to dryness
出典と根拠
- ORDレコード
- ord-4e3f3970edc94e6e9c8dc563cecca0a1
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06413975B1
反応ノート
読み込み中…