p-Toluenesulfonic acid → HCID 178475406、化合物

HRID 22276

反応式

HRID 22276 の反応式
[C:1]1([N:7]2[CH2:11][CH2:10][C:9]([NH2:12])=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]([O:16][C:17]1[C:22]([CH3:23])=[CH:21][C:20](N)=[CH:19][C:18]=1[CH3:25])(=[O:15])[CH3:14].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[C:13]([O:16][C:17]1[C:22]([CH3:23])=[CH:21][C:20]([NH:12][C:9]2[CH2:10][CH2:11][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:8]=2)=[CH:19][C:18]=1[CH3:25])(=[O:15])[CH3:14]

参加物

5

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 987363-Amino-1-phenylpyrazoleHCID 15231609HCID 15231609、化合物

生成物 1

HCID 178475406HCID 178475406、化合物収率 46.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

4,5-Dihydro-1-phenyl-1H-pyrazol-3-amine (0.16 g), 4-amino-2,6-dimethylphenyl acetate (0.2 g), and toluene-4-sulfonic acid (0.02 g) were refluxed in toluene under nitrogen for 8 hours. Evaporation and chromatography (silica, dichloromethane/ethyl acetate [95:5]) of the residue gave the title product (0.15 g), as a solid.

後処理

  1. customEvaporation and chromatography (silica, dichloromethane/ethyl acetate [95:5]) of the residue

出典と根拠

ORDレコード
ord-6a05132bb6f6479fa1f6059fc1b38eb9
出典データセット
uspto-grants-1995_06
特許番号
US05428044

関連ノート

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