Imidazole → 2-(Imidazol-1-yl)-1-(thiazol-2-yl)-ethanone
反応式
Br[CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][N:9]=1)=[O:4].[NH:10]1[CH:14]=[CH:13][N:12]=[CH:11]1>CC#N>[N:10]1([CH2:2][C:3]([C:5]2[S:6][CH:7]=[CH:8][N:9]=2)=[O:4])[CH:14]=[CH:13][N:12]=[CH:11]1参加物
4
実験手順
To a solution of 2-bromo-1-(thiazol-2-yl)-ethanone (2.5 g; 12 mmol) in CH3CN (70 ml) was added imidazole (1.65 g; 24 mmol). After stirring at room temperature for 1 hour, the mixture was evaporated to dryness and partitioned between CH2Cl2 and water. The organics were washed with saturated NaCl and evaporated to give 2-(imidazol-1-yl)-1-(thiazol-2-yl)-ethanone as a brown solid (1.17 g; 50%).
後処理
- customthe mixture was evaporated to dryness
- custompartitioned between CH2Cl2 and water
- washThe organics were washed with saturated NaCl
- customevaporated
出典と根拠
- ORDレコード
- ord-1435ee3ee7924a32aae9baa5478f7dea
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06414145B1
反応ノート
読み込み中…