Ethanol → Aminolevulinic acid phosphate

HRID 222819

反応式

HRID 222819 の反応式
Cl.[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8].[P:11](=[O:15])([OH:14])([OH:13])[OH:12].N1C=CC(C)=CC=1.C(O)C>O>[P:11]([OH:15])([OH:14])([OH:13])=[O:12].[NH2:2][CH2:3][C:4](=[O:10])[CH2:5][CH2:6][C:7]([OH:9])=[O:8]

参加物

6

反応物 4

HCID 702EthanolHCID 1004Phosphoric AcidHCID 79634-MethylpyridineHCID 123608Aminolevulinic Acid Hydrochloride

生成物 1

HCID 24737828Aminolevulinic acid phosphate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 10.05 g (60.6 mmol) portion of δ-aminolevulinic acid hydrochloride and 4.5 ml (65.7 mmol) of 85% phosphoric acid were dissolved in 30 ml of purified water, and 5.83 g (62.7 mmol) of γ-picoline was added dropwise thereto while stirring. After completion of the dropwise addition and subsequent stirring at room temperature for 10 minutes, 400 ml of ethanol was added thereto and stirred. The thus precipitated precipitate was recovered by suction filtration and dried at room temperature for 19 hours under a reduced pressure. A 10.55 g (46.1 mmol) portion of δ-aminolevulinic acid phosphate was obtained at a yield of 77 mol %.

後処理

  1. additionAfter completion of the dropwise addition
  2. stirringsubsequent stirring at room temperature for 10 minutes
  3. stirringstirred
  4. filtrationThe thus precipitated precipitate was recovered by suction filtration
  5. customdried at room temperature for 19 hours under a reduced pressure

出典と根拠

ORDレコード
ord-901946f65deb420a9baf0c01fe95683c
出典データセット
uspto-grants-2012_06
特許番号
US08207376B2

関連ノート

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