Hydrochloric Acid → 3-(5-(p-Tolyl)furan-2-yl)acrylic acid

HRID 2228211ノート

反応式

HRID 2228211 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11](/[CH:13]=[CH:14]/[C:15]([O:17]C)=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>O1CCCC1CCO>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][C:11](/[CH:13]=[CH:14]/[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86756170methyl (E)-3-[5-(4-methylphenyl)furan-2-yl]acrylate

生成物 1

HCID 62642823-(5-(p-Tolyl)furan-2-yl)acrylic acid収率 66.3%

試薬・触媒・溶媒 1

HCID 119895722-(Oxolan-2-yl)ethan-1-ol溶媒

実験手順

To a solution of methyl (E)-3-[5—(4-methylphenyl)-furan-2-yl]acrylate (1.49 g) in tetrahydrofuran-ethanol (10-10 ml) was added 2N sodium hydroxide (4 ml) at room temperature, and the mixture was stirred for 24 hours. The reaction mixture was acidified with 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried with magnesium sulfate and concentrated under reduced pressure to give (E)-3-[5—(4-methylphenyl)-furan-2-yl]acrylic acid (0.93 g) as colorless crystals.

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated sodium chloride solution
  3. dry with materialdried with magnesium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-79b0f4484a024c4693a00c7b06c94e64
出典データセット
uspto-grants-2002_07
特許番号
US06413947B1

反応ノート

読み込み中…