HCID 87950499、化合物 → HCID 18469986、化合物

HRID 2228448ノート

反応式

HRID 2228448 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:36])[CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:35])[C:31]([F:34])([F:33])[F:32])=[CH:25][CH:24]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[F:33][C:31]([F:32])([F:34])[C:30]([NH:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][CH2:21][C:20](=[O:36])[C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:15][CH:16]=2)=[CH:28][CH:27]=1)=[O:35]

参加物

4

反応物 1

HCID 87950499HCID 87950499、化合物

生成物 1

HCID 18469986HCID 18469986、化合物収率 96.2%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A suspension of 4-(4-{3-[4-(2,2,2-trifluoroacetylamino)phenyl]propionyl}-phenyl)piperazine-1-carboxylic acid tert-butyl ester (2.5 g, 4.95 mmol) in dichloromethane (10 mL) and trifluoroacetic acid (10 mL) was stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo and diluted with water. The resultant white solid was collected, washed with water, dried in vacuo to give the title compound (1.93 g, 96%). The product was used in the next step without further purification.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water
  3. customThe resultant white solid was collected
  4. washwashed with water
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-9c4ad7f779a94c68a26c37476c9eec9a
出典データセット
uspto-grants-2002_07
特許番号
US06417186B1

反応ノート

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