2-Benzyloxy-3,4-dimethoxybenzonitrile → 2-Hydroxy-3,4-dimethoxybenzonitrile
反応式
C([O:8][C:9]1[C:16]([O:17][CH3:18])=[C:15]([O:19][CH3:20])[CH:14]=[CH:13][C:10]=1[C:11]#[N:12])C1C=CC=CC=1>[Pd].C(O)C>[OH:8][C:9]1[C:16]([O:17][CH3:18])=[C:15]([O:19][CH3:20])[CH:14]=[CH:13][C:10]=1[C:11]#[N:12]参加物
4
実験手順
10% palladium on charcoal (2.0 g) was added to a solution of 2-benzyloxy-3,4-dimethoxybenzonitrile (20.8 g, 0.077 mol) in ethanol (250 ml) and the reaction stirred under a hydrogen atmosphere of 414 kPa (60 p.s.i.) for 4 hours. On cooling, the mixture was filtered through Arbocel™, washing with further ethanol. The filtrate was evaporated under reduced pressure to give the subtitle compound as a yellow solid (13.37 g, 97%). Rf 0.19 (dichloromethane). MS m/z 197 (MNH4)+.
後処理
- temperatureOn cooling
- filtrationthe mixture was filtered through Arbocel™
- washwashing with further ethanol
- customThe filtrate was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-6cbe3970b6884e909c76703a8dd8bf4b
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06417194B1
反応ノート
読み込み中…