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Benzophenone → Benzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzophenone | HCID 3102 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Aminoacetonitrile sulfate (1:1) | HCID 196971 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Benzimidazole | HCID 5798 | 156,273.703% |
反応手順
To a stirred solution of 2-aminoacetonitrile bisulfate (2.9 g, 0.013 mmol) in dichloromethane (50 mL) was added benzophenone (3.48 mL, 0.0208 mmol) followed by DIEA (4.53 mL, 0.026 mmol). After stirring 18 h, the dichloromethane solution was washed with water (50 mL), dried over sodium sulfate, filtered, and the filtrate concentrated under reduced pressure. The residue was purified on a flash silica gel column (hexanes:EtOAc, 1:1) to give 3 (2.40 g, 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08207340B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-135c9da0779349ac950e1ffb03afbab9 |
| 出典メモ | uspto-grants-2012_06 |