反应详情

To a stirred solution of 2-aminoacetonitrile bisulfate (2.9 g, 0.013 mmol) in dichloromethane (50 mL) was added benzophenone (3.48 mL, 0.0208 mmol) followed by DIEA (4.53 mL, 0.026 mmol). After stirring 18 h, the dichloromethane solution was washed with water (50 mL), dried over sodium sulfate, filtered, and the filtrate concentrated under reduced pressure. The residue was purified on a flash silica gel column (hexanes:EtOAc, 1:1) to give 3 (2.40 g, 82%).

1. washthe dichloromethane solution was washed with water (50 mL)
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. concentrationthe filtrate concentrated under reduced pressure
5. customThe residue was purified on a flash silica gel column (hexanes:EtOAc, 1:1)