Ethyl 3-(pyrimidin-5-yl)prop-2-enoate → Ethyl 3-(5-pyrimidyl)propionate

HRID 2228908ノート

反応式

HRID 2228908 の反応式
[N:1]1[CH:6]=[C:5]([CH:7]=[CH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:4]=[N:3][CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:4]=[N:3][CH:2]=1

参加物

4

反応物 1

HCID 53438539Ethyl 3-(pyrimidin-5-yl)prop-2-enoate

生成物 1

HCID 21936199Ethyl 3-(5-pyrimidyl)propionate収率 47.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 3-(5-pyrimidyl)acrylate (4.75 g) in ethanol (90 ml) was added 5% palladium on charcoal (0.2 g). The mixture was hydrogenated at an initial pressure of 50 psi, then filtered to remove catalyst and the solvent evaporated. Water was added, and the product extracted into ether. Drying, charcoaling and evaporation gave ethyl 3-(5-pyrimidyl)propionate (2.3 g) as a yellow oil. 1H-NMR (CDCl3) δ 1.23 (3H, t), 2.69 (2H, t), 2.96 (2H, t), 4.14 (2H, q), 8.635 (2H, s) and 9.09 (1H, s).

後処理

  1. filtrationfiltered
  2. customto remove catalyst
  3. customthe solvent evaporated
  4. additionWater was added
  5. extractionthe product extracted into ether
  6. customDrying
  7. customcharcoaling and evaporation

出典と根拠

ORDレコード
ord-5845df4c4a6b4e97b04c1c946e30da3a
出典データセット
uspto-grants-2002_07
特許番号
US06417192B1

反応ノート

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