Hydrazine hydrate (1:1) → 2-hydrazono-1-phenylpropan-1-one O-methyl oxime

HRID 2229132ノート

反応式

HRID 2229132 の反応式
[CH3:1][O:2][N:3]=[C:4]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](=O)[CH3:6].O.[NH2:15][NH2:16]>C(O)C>[CH3:1][O:2][N:3]=[C:4]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](=[N:15][NH2:16])[CH3:6]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 539446061-phenylpropane-1,2-dione 1-(O-methyl oxime)

生成物 1

HCID 572718472-hydrazono-1-phenylpropan-1-one O-methyl oxime収率 56%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.5 g (0.014 mol) of 1-phenylpropane-1,2-dione 1-(O-methyl oxime) are heated at 60° C. in 20 ml of ethanol with 1.45 g (0.029 mol) of hydrazine hydrate for 1 hour. The reaction mixture is poured onto water and extracted with diethyl ether, the organic phase is dried over sodium sulphate and the solvent is distilled off in vacuo. The residue is stirred with diethyl ether and the crystals are filtered off. 1.5 g (55.6% of theory) of 2-hydrazono-1-phenylpropan-1-one O-methyl oxime of melting point 132° C. are obtained.

後処理

  1. additionThe reaction mixture is poured onto water
  2. extractionextracted with diethyl ether
  3. dry with materialthe organic phase is dried over sodium sulphate
  4. distillationthe solvent is distilled off in vacuo
  5. filtrationthe crystals are filtered off

出典と根拠

ORDレコード
ord-f451d3764de9463eaa794004fca71fa6
出典データセット
uspto-grants-2002_07
特許番号
US06420362B1

反応ノート

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