Methanol → Methyl 3-chloro-4-isopropoxybenzoate

HRID 222925

反応式

HRID 222925 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH:12]([CH3:14])[CH3:13])[C:5]([OH:7])=[O:6].O=S(Cl)Cl.[CH3:19]O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH:12]([CH3:14])[CH3:13])[C:5]([O:7][CH3:19])=[O:6]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 225977283-Chloro-4-(propan-2-yloxy)benzoic acid

生成物 1

HCID 22597811Methyl 3-chloro-4-isopropoxybenzoate

実験手順

A solution of 3-chloro-4-[(1-methylethyl)oxy]benzoic acid (1.00 g, 4.66 mmol) in methanol (10.0 mL) was treated with SOCl2 (0.68 mL, 9.32 mmol). After stirring overnight at ambient temperature, the solution was concentrated in vacuo and taken on without purification. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 8.04 (d, J=2.3 Hz, 1H) 7.89 (dd, J=8.7, 2.1 Hz, 1H) 6.93 (d, J=8.6 Hz, 1H) 4.66 (qq, J=6.1 Hz, 1H) 3.88 (s, 3H) 1.41 (d, J=6.1 Hz, 6H). MS (ES+) m/e 229 [M+H]+.

後処理

  1. concentrationthe solution was concentrated in vacuo
  2. customtaken on without purification

出典と根拠

ORDレコード
ord-d598efe57d44464c8ca78922e0459f1e
出典データセット
uspto-grants-2012_06
特許番号
US08207340B2

関連ノート

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