Gamma-Butyrolactone → 4-Hydroxy-1-(2-naphthyl)-1-butanone

温度

-78 °C

To a cooled (−78° C.) solution of 2-bromonaphthalene (10.77 g) in THF (150 ml) was added n-BuLi in hexane (1.65M, 36 ml) and the mixture was stirred at −78° C. for 30 minutes. To the solution was added γ-butyrolactone (25 ml) and the mixture was stirred at −78° C. for 1 minute. Aqueous solution of NH4Cl was added and the mixture was extracted with ethyl acetate. The extract was washed with aqueous NH4Cl solution, water and brine, dried and concentrated. The residue was chromatographed on silica gel (hexane:ethyl acetate=3:1) followed by recrystallization from cyclohexane-ethyl acetate to give the titled compound (6.71 g) as a colorless solid.

1. stirringthe mixture was stirred at −78° C. for 1 minute
2. extractionthe mixture was extracted with ethyl acetate
3. washThe extract was washed with aqueous NH4Cl solution, water and brine
4. customdried
5. concentrationconcentrated
6. customThe residue was chromatographed on silica gel (hexane:ethyl acetate=3:1)
7. customfollowed by recrystallization from cyclohexane-ethyl acetate

ORDレコード

ord-3a2a7b57dbe9461c8a11e1ab97deb6dc

出典データセット

uspto-grants-2002_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06420375B1