Nitric Acid → 2,4,6-Trimethyl-3-nitrobenzoic acid

HRID 2229914ノート

反応式

HRID 2229914 の反応式
[CH3:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[C:3]=1[C:4]([OH:6])=[O:5].[N+:13]([O-])([OH:15])=[O:14]>>[N+:13]([C:10]1[C:2]([CH3:1])=[C:3]([C:7]([CH3:12])=[CH:8][C:9]=1[CH3:11])[C:4]([OH:6])=[O:5])([O-:15])=[O:14]

参加物

3

反応物 2

HCID 944Nitric AcidHCID 101942,4,6-Trimethylbenzoic acid

生成物 1

HCID 81670772,4,6-Trimethyl-3-nitrobenzoic acid収率 94%

実験手順

To a suspension of 2,4,6-trimethylbenzoic acid (4.6 g, 28 mmol) in 70% HNO3 (85 mL) conc. H2SO4 (5 mL). was added dropwise at RT. The brown reaction mixture was stirred for 1 h, poured into ice-water (500 mL). The product was extracted into ethyl acetate, the extract was washed with water, dried over MgSO4 and concentrated to give 3-nitro-2,4,6-trimethylbenzoic acid as a yellow solid (6.7 g, 94%).

後処理

  1. additionwas added dropwise at RT
  2. extractionThe product was extracted into ethyl acetate
  3. washthe extract was washed with water
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-f1e8cfe21cd74920b3bed88be65124d6
出典データセット
uspto-grants-2002_07
特許番号
US06420567B1

反応ノート

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