Ethyl acetamidate hydrochloride → HCID 131723418、化合物

HRID 2230392

反応式

HRID 2230392 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[NH:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[C:8]=2[C:19]2[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=2)[CH2:3][CH2:2]1.CCO[C:28]([C:30]([NH2:32])=[O:31])=[O:29].Cl>CCO>[C:28]1(=[O:29])[N:32]([N:1]2[CH2:2][CH2:3][CH:4]([C:7]3[NH:11][N:10]=[C:9]([C:12]4[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=4)[C:8]=3[C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)[CH2:5][CH2:6]2)[C:30]1=[O:31]

参加物

4

反応物 2

HCID 19983589Ethyl acetamidate hydrochlorideHCID 22037479HCID 22037479、化合物

生成物 1

HCID 131723418HCID 131723418、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 5-(4-piperidyl)-4-(4-pyridyl)-3-(4-fluorophenyl)pyrazole (Example C-2) (0.11 g, 0.35 mmol) in 2 mL EtOH was added ethyl acetamidate hydrochloride (0.065 g, 0.53 mmol) and the mixture was refluxed for 30 minutes. The solution was left at 5-10° C. for 16 h and filtered to obtain the title compound as a white solid: MS (M+H): 364 (base peak).

後処理

  1. temperaturethe mixture was refluxed for 30 minutes
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-7221527b57da424dade102d6b22d56bf
出典データセット
uspto-grants-2002_07
特許番号
US06423713B1

関連ノート

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