Hydrochloric Acid → 2-Methylthio-5-(1H-tetrazol-1-yl)benzoic Acid
反応式
[CH3:1][S:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>CO>[CH3:1][S:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]参加物
5
実験手順
Combine methyl 2-methylthio-5-(1H-tetrazol-1-yl)benzoate (0.5 g, 2.0 mmol) and a 1 M aqueous solution of sodium hydroxide (20 mL, 20 mmol) in methanol (20 mL). After 2 hours, adjust the pH to about 2 using a 1 M aqueous hydrochloric acid solution and extract with ethyl acetate. Dry the organic layer over MgSO4, filter, and concentrate in vacuo to give the title compound: Rf=0.70 (silica gel, 10% methanol/85% chloroform/5% acetic acid).
後処理
- extractionextract with ethyl acetate
- dry with materialDry the organic layer over MgSO4
- filtrationfilter
- concentrationconcentrate in vacuo
出典と根拠
- ORDレコード
- ord-c228f2835a72430ea82d902460492a49
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06423704B1
反応ノート
読み込み中…