Hydrochloric Acid → 2-chloro-3,4,5-trimethoxybenzoic Acid
反応式
[Cl:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[C:9]([O:16][CH3:17])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[C:9]([O:16][CH3:17])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]参加物
5
実験手順
Combine methyl 2-chloro-3,4,5-trimethoxybenzoate (2.0 g, 7.8 mmol) and a 1 M aqueous solution of sodium hydroxide (100 mL, 100 mmol) in methanol (50 mL). After 6 hours, adjust the pH to about 2 using a 1 M aqueous hydrochloric acid solution and extract with dichloromethane. Dry the combined organic layers over MgSO4, filter, and concentrate in vacuo to give the title compound: Rf=0.81 (silica gel, 10% methanol/85% c.hloroform/5% acetic acid).
後処理
- extractionextract with dichloromethane
- dry with materialDry the combined organic layers over MgSO4
- filtrationfilter
- concentrationconcentrate in vacuo
出典と根拠
- ORDレコード
- ord-0fcfe378be764b328036d2fab499c1ab
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06423704B1
反応ノート
読み込み中…