Ethylenediamine → Clonidine

HRID 2231167

反応式

HRID 2231167 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1S(O)(=O)=O.[CH2:13]([NH2:16])[CH2:14][NH2:15].[C:17](#[N:19])C>>[CH:6]1[CH:7]=[C:2]([Cl:1])[C:3]([NH:19][C:17]2[NH:16][CH2:13][CH2:14][N:15]=2)=[C:4]([Cl:8])[CH:5]=1

参加物

4

反応物 3

HCID 3301EthylenediamineHCID 6342AcetonitrileHCID 40513242,6-dichlorobenzenesulfonic Acid

生成物 1

HCID 2803Clonidine

反応条件

温度
65 °C

実験手順

2,6-dichlorophenylsulfonic acid (1.0 g, 0.0037 m) was added to ethylenediamine (0.5 g, 0.008 m) in the absence of solvent. The reaction exothermed to 35° C. and was diluted with acetonitrile and heated at 65° C. for 7.25 hr. The reaction was concentrated, treated with sodium hydroxide and extracted with methylene chloride. The organic phase was dried and concentrated to yield 0.5 g of clonidine. The product was identified by spectroscopic methods.

後処理

  1. customexothermed to 35° C.
  2. concentrationThe reaction was concentrated
  3. additiontreated with sodium hydroxide
  4. extractionextracted with methylene chloride
  5. customThe organic phase was dried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-9868b38f873b4a8fa7a6c48a028fab4f
出典データセット
uspto-grants-1988_11
特許番号
US04781866

関連ノート

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