4'-(Benzyloxy)-5-hydroxy-3,3',7-trimethoxyflavone → Pachypodol

HRID 223126

反応式

HRID 223126 の反応式
C([O:8][C:9]1[CH:30]=[CH:29][C:12]([C:13]2[O:14][C:15]3[C:20]([C:21](=[O:25])[C:22]=2[O:23][CH3:24])=[C:19]([OH:26])[CH:18]=[C:17]([O:27][CH3:28])[CH:16]=3)=[CH:11][C:10]=1[O:31][CH3:32])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:30]=[CH:29][C:12]([C:13]2[O:14][C:15]3[C:20]([C:21](=[O:25])[C:22]=2[O:23][CH3:24])=[C:19]([OH:26])[CH:18]=[C:17]([O:27][CH3:28])[CH:16]=3)=[CH:11][C:10]=1[O:31][CH3:32]

参加物

4

反応物 1

HCID 205225384'-(Benzyloxy)-5-hydroxy-3,3',7-trimethoxyflavone

生成物 1

HCID 5281677Pachypodol収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 0.86 g of 4'-(benzyloxy)-5-hydroxy-3,3',7-trimethoxyflavone in 30 ml of ethanol was hydrogenated in the presence of 50 mg of 5% by weight palladium-charcoal at room temperature under atmospheric pressure. After 1 hour, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The residue was recrystallized from ethyl acetate/hexane. There was obtained 0.58 g (90% yield) of 4',5-dihydroxy-3,3',7-trimethoxyflavone as yellow crystals: m.p. 171°-173° C.

後処理

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe residue was recrystallized from ethyl acetate/hexane

出典と根拠

ORDレコード
ord-cae083b04b604fb787ca83968020b153
出典データセット
uspto-grants-1982_10
特許番号
US04352792

関連ノート

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