Trifluoroacetic acid → HCID 54340399、化合物
反応式
C([O:5][C:6]([CH2:8][O:9][N:10]=[C:11]([CH:15]=[C:16]([CH2:22][CH3:23])[CH:17]([N+:19]([O-:21])=[O:20])[CH3:18])[C:12]([NH2:14])=[O:13])=[O:7])(C)(C)C.FC(F)(F)C(O)=O>>[C:6]([CH2:8][O:9][N:10]=[C:11]([CH:15]=[C:16]([CH2:22][CH3:23])[CH:17]([N+:19]([O-:21])=[O:20])[CH3:18])[C:12]([NH2:14])=[O:13])([OH:7])=[O:5]参加物
3
実験手順
2-t-Butoxycarbonylmethoxyimino-4-ethyl-5-nitro-3-hexenamide (80 mg) was treated with trifluoroacetic acid (1 ml) at ambient temperature for 2 hours. Excess trifluoroacetic acid was distilled off under reduced pressure to give a residue which was purified by preparative thin layer chromatography, eluting with a mixture of benzene, dioxane and acetic acid (14:5:1) to give 2-carboxymethoxyimino-4-ethyl-5-nitro-3-hexenamide (32 mg).
後処理
- distillationExcess trifluoroacetic acid was distilled off under reduced pressure
- customto give a residue which
- customwas purified by preparative thin layer chromatography