Sodium Hydroxide → 3-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid

HRID 2231366ノート

反応式

HRID 2231366 の反応式
F[C:2]1[CH:15]=[CH:14][C:5]([C:6]([CH:8]([CH3:13])[CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1.[OH-].[Na+]>O>[O:16]=[C:17]1[CH:22]=[CH:21][N:20]([C:2]2[CH:15]=[CH:14][C:5]([C:6]([CH:8]([CH3:13])[CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=2)[CH:19]=[CH:18]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 124495243-(4-Fluorobenzoyl)butanoic acidHCID 178418642HCID 178418642、化合物

生成物 1

HCID 99477483-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of 3-(4-fluorobenzoyl)butanoic acid (885 g), 4-hydroxypyridine (663 g) and sodium hydroxide (453 g) in water (2.2 liters) was stirred under reflux for 24 hours. The reaction mixture was cooled, diluted with water (10 liters) and filtered through diatomaceous earth. The filtrate was acidified to pH 3 with concentrated hydrochloric acid to afford as a cream solid 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid, 1127 g (94%), m.p. 251°-254° C.

後処理

  1. temperatureunder reflux for 24 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered through diatomaceous earth

出典と根拠

ORDレコード
ord-9315b0928757414090e98232b2951f49
出典データセット
uspto-grants-1988_11
特許番号
US04782159

反応ノート

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