Sulfuric Acid → HCID 20523213、化合物

反応式

[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2].S(=O)(=O)(O)O.[N+:20]([O-])([O-:22])=[O:21].[K+]>>[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[C:9]([N+:20]([O-:22])=[O:21])[CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2]

参加物

反応物 3

HCID 1118Sulfuric Acid2 回

HCID 24434Potassium Nitrate

HCID 12838039HCID 12838039、化合物

生成物 1

HCID 20523213HCID 20523213、化合物

実験手順

A solution of 20.9 g. (0.1 mole) of 2-acetyl-7-chloro-1,2,3,4-tetrahydroisoquinoline in 100 ml. of concentrated sulfuric acid is treated with 10 g. (0.1 mole) of potassium nitrate dissolved in 150 ml. of concentrated sulfuric acid. The mixture is stirred for one hour, quenched on ice, made alkaline with ammonium hydroxide and filtered to yield 2-acetyl-7-chloro-6-nitro-1,2,3,4-tetrahydroisoquinoline.