Hydrogen Bromide → 113884-76-7
反応式
Cl.C[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14]C)[CH:10]=[N:9][CH:8]=[CH:7]2.[BrH:16]>>[BrH:16].[OH:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[OH:14])[CH:10]=[N:9][CH:8]=[CH:7]2参加物
3
実験手順
63.4 g (0.28 mol) of 6,7-dimethoxyisoquinoline hydrochloride was dissolved in 630 ml of 47% hydrobromic acid, and the mixture was refluxed for 24 hours under stirring in nitrogen atmosphere. The reaction mixture was allowed to stand still under cooling with ice. The crystals formed were collected by filtration and washed with cold water and acetone. They were dried in air overnight and then dried at a temperature of from 90° to 95° C. for 6 hours to obtain 66.4 g (yield: 97.6%) of the above identified compound.
後処理
- temperaturethe mixture was refluxed for 24 hours
- temperatureunder cooling with ice
- customThe crystals formed
- filtrationwere collected by filtration
- washwashed with cold water and acetone
- customThey were dried in air overnight
- customdried at a temperature of from 90° to 95° C. for 6 hours
- customto obtain 66.4 g (yield: 97.6%) of the
出典と根拠
- ORDレコード
- ord-b1790ec008744d5cac8ad4aa2ffd039b
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04782155
反応ノート
読み込み中…