Sodium Carbonate → 2-(2-Pyridyl)thiazolo[3,2-a]benzimidazole
反応式
[SH:1][C:2]1[N:6]([CH2:7][C:8](=O)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[C:5]2[CH:16]=[CH:17][CH:18]=[CH:19][C:4]=2[N:3]=1.C([O-])([O-])=O.[Na+].[Na+]>>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:8]1[S:1][C:2]2=[N:3][C:4]3[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=3[N:6]2[CH:7]=1参加物
3
実験手順
A solution of 2-mercapto-1-[2-oxo-2-(2-pyridyl)ethyl]benzimidazole (1 g.) in polyphosphoric acid was heated at 140° C. for 1 hour. The solution was neutralised with Na2CO3 solution and extracted into EtOAc (700 ml). The extracts were dried (MgSO4) and evaporated to give a solid which was recrystallised from EtOAc/EtOH to give the title compound (0.35 g.) mp 222°-4° C.
後処理
- extractionextracted into EtOAc (700 ml)
- dry with materialThe extracts were dried (MgSO4)
- customevaporated
- customto give a solid which
- customwas recrystallised from EtOAc/EtOH
出典と根拠
- ORDレコード
- ord-3755b4504c1f4712b9fd4451aa232c60
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04786636
反応ノート
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