Sodium Azide → HCID 14347788、化合物
反応式
[CH2:1]([N:8]1[CH2:12][CH:11]([OH:13])[CH:10]([CH2:14]S(C)(=O)=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:19]=[N+:20]=[N-:21].[Na+]>CO.O>[CH2:1]([N:8]1[CH2:12][CH:11]([OH:13])[CH:10]([CH2:14][N:19]=[N+:20]=[N-:21])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
1-Benzyl-4-hydroxy-3-methanesulfonylmethylpyrrolidine (80.8 g) is added to methanol-water (3:2) (1 liter), and thereto is added dropwise sodium azide (24.5 g), and the mixture is refluxed for 24 hours. After the reaction, the mixture is concentrated and extracted with dichloromethane. The dichloromethane solution is washed with water and saturated saline, dried and concentrated to give 1-benzyl-4-hydroxy-3-azidomethylpyrrolidine (59.7 g) as an oil.
後処理
- temperaturethe mixture is refluxed for 24 hours
- customAfter the reaction
- concentrationthe mixture is concentrated
- extractionextracted with dichloromethane
- washThe dichloromethane solution is washed with water and saturated saline
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-fea7f18239074fdd98a287d80d88940a
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04786649
反応ノート
読み込み中…