Methanol → HCID 86250420、化合物

HRID 2232094ノート

反応式

HRID 2232094 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=[N:9][OH:10])[CH3:8])=[CH:3][CH:2]=1.[BH4-].[Na+].[CH3:13]O>>[CH3:13][N:1]1[CH2:6][CH:5]=[C:4]([C:7](=[N:9][OH:10])[CH3:8])[CH2:3][CH2:2]1

参加物

4

反応物 3

HCID 887Methanol2 回HCID 247997Ethanone, 1-(4-pyridinyl)-, oximeHCID 4311764Sodium borohydride

生成物 1

HCID 86250420HCID 86250420、化合物

実験手順

A solution of 1-(4-pyridinyl)ethanone oxime, methiodide (48.36 g, 174 mmol) in 200 ml of 50% aqueous methanol was added to a cooled (-5° C.) slurry of sodium borohydride (12.86 g, 340 mmol) in 200 ml 50% aqueous methanol and the reaction mixture was stirred one hour. After some inorganic material was removed by filtration, the methanol was distilled off the filtrate in vacuo. The resulting solid was collected by filtration and dried to provide 1-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)ethanone oxime (18 g), mp 166°-168° C.

後処理

  1. customAfter some inorganic material was removed by filtration
  2. distillationthe methanol was distilled off the filtrate in vacuo
  3. filtrationThe resulting solid was collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-bcac5a59686941e4b9bbd19029e6859a
出典データセット
uspto-grants-1988_11
特許番号
US04786648

反応ノート

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