Hydrochloric Acid → 5-Amino-1-(2,3,5,6-tetrafluoro-4-trifluoromethylphenyl)-4-nitropyrazole

HRID 2232179ノート

反応式

HRID 2232179 の反応式
C([NH:4][C:5]1[N:9]([C:10]2[C:15]([F:16])=[C:14]([F:17])[C:13]([C:18]([F:21])([F:20])[F:19])=[C:12]([F:22])[C:11]=2[F:23])[N:8]=[CH:7][C:6]=1[N+:24]([O-:26])=[O:25])(=O)C.Cl.C(O)C.[OH-].[Na+]>O>[NH2:4][C:5]1[N:9]([C:10]2[C:15]([F:16])=[C:14]([F:17])[C:13]([C:18]([F:20])([F:21])[F:19])=[C:12]([F:22])[C:11]=2[F:23])[N:8]=[CH:7][C:6]=1[N+:24]([O-:26])=[O:25]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702Ethanol2 回HCID 14798Sodium HydroxideHCID 139337121-(2,3,5,6-Tetrafluoro-4-trifluoromethyl phenyl)-5-methylcarbonylamino-4-nitropyrazole

生成物 1

HCID 139337135-Amino-1-(2,3,5,6-tetrafluoro-4-trifluoromethylphenyl)-4-nitropyrazole収率 91.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

19.3 g (0.05 mol) of 5-acetamido-4-nitro-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole are heated under reflux in a mixture of 40 ml of 37 percent strength hydrochloric acid and 70 ml of ethanol for 7 hours. The reaction mixture is freed from the ethanol in vacuo. 35 ml of water are added to the residue and the mixture is neutralized with dilute sodium hydroxide solution. The precipitate is filtered off with suction, washed with water and dried in vacuo. 15.7 g (91.4% of theory) of 5-amino-4-nitro-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole of melting point 123° C.-126° C. are obtained.

後処理

  1. filtrationThe precipitate is filtered off with suction
  2. washwashed with water
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-24b7690c4d3a421da3e961e4dcf7f517
出典データセット
uspto-grants-1988_11
特許番号
US04787930

反応ノート

読み込み中…