化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → (+/-)-6-{3-[4-(bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl]-2-hydroxypropoxy}-7-methoxy-2H-1-benzopyran-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| 反応物 | 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one | HCID 19927672 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | (+/-)-6-{3-[4-(bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl]-2-hydroxypropoxy}-7-methoxy-2H-1-benzopyran-2-one | HCID 19927676 | 45% |
反応手順
Method C (5 d at 45° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 4-[bis(4-fluorophenyl)hydroxymethyl]piperidine; yield 45%; fusion point 220°-221° C. (from methanol and chloroform). Hydrochloride: method G; yield 99%; fusion point 172°-174° C. (from isopropanol and ethanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05428038 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-27e1f705903044f48f64c5fe115171f8 |
| 出典メモ | uspto-grants-1995_06 |