HRID22323

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID887

Methanol

CH4O

HCID11208889

bis(4-fluorophenyl)(piperidin-4-yl)methanol

C18H19F2NO

HCID19927672

未命名化合物

PRODUCTS

生成物

结构：COc1cc2oc(=O)ccc2cc1OCC(O)CN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1

HCID19927676

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID3776

Isopropanol

C3H8O

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Method C (5 d at 45° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 4-[bis(4-fluorophenyl)hydroxymethyl]piperidine; yield 45%; fusion point 220°-221° C. (from methanol and chloroform). Hydrochloride: method G; yield 99%; fusion point 172°-174° C. (from isopropanol and ethanol).

WORKUP

后处理

customMethod C (5 d at 45° C.)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-27e1f705903044f48f64c5fe115171f8
来源数据集: uspto-grants-1995_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05428038
来源说明: uspto-grants-1995_06

反应 SMILES

[CH3:1][O:2][C:3]1[C:13]([O:14][CH2:15][CH:16]2[CH2:18][O:17]2)=[CH:12][C:6]2[CH:7]=[CH:8][C:9](=[O:11])[O:10][C:5]=2[CH:4]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)([OH:33])[CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:22][CH:21]=1.CO.Cl>C(O)C.C(O)(C)C.C(Cl)(Cl)Cl>[F:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([C:34]2[CH:35]=[CH:36][C:37]([F:40])=[CH:38][CH:39]=2)([OH:33])[CH:27]2[CH2:28][CH2:29][N:30]([CH2:18][CH:16]([OH:17])[CH2:15][O:14][C:13]3[C:3]([O:2][CH3:1])=[CH:4][C:5]4[O:10][C:9](=[O:11])[CH:8]=[CH:7][C:6]=4[CH:12]=3)[CH2:31][CH2:32]2)=[CH:22][CH:21]=1