Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate) → 1-(2-chloroethoxy)-3-nitrobenzene

HRID 2232318ノート

反応式

HRID 2232318 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[Cl:17][CH2:18][CH2:19]OS(C1C=CC(C)=CC=1)(=O)=O>CC(=O)CC>[Cl:17][CH2:18][CH2:19][O:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

参加物

5

反応物 3

HCID 6639Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate)HCID 111373-NitrophenolHCID 11430Potassium Carbonate

生成物 1

HCID 43044241-(2-chloroethoxy)-3-nitrobenzene

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 6.96 g. of m-nitrophenol, 100 ml. of 2-butanone, 6.9 g. of potassium carbonate, and 11.74 g. of 2 chloroethyl-tosylate was stirred and heated under reflux for 24 hours. After cooling to room temperature, the salts were filtered off and the filtrate concentrated under vacuum. The residue crystallized on seeding and was recrystallized from carbon tetrachloride to give 8.3 g. of product, m.p. 54.5°-57° C.

後処理

  1. additionA mixture of 6.96 g
  2. temperatureheated
  3. temperatureunder reflux for 24 hours
  4. filtrationthe salts were filtered off
  5. concentrationthe filtrate concentrated under vacuum
  6. customThe residue crystallized on seeding
  7. customwas recrystallized from carbon tetrachloride
  8. customto give 8.3 g

出典と根拠

ORDレコード
ord-e7eec975577a49738e06e58d397b4c33
出典データセット
uspto-grants-1988_11
特許番号
US04788195

反応ノート

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